ObjectiveTo examine the prevalence and predictors of screening for violence against persons and victim service utilization within an integrated safety-net health system.Study SettingEmergency Department (ED) at Parkland Hospital—Dallas County's largest safety-net provider of services for minority and underinsured and uninsured patients.Study DesignProspective, longitudinal study during the first 6 months of a universal violence against persons screener.Data CollectionHealth records were extracted for all patients with a visit to the ED between January and July, 2021. Modeling described the patient population across screening (screened vs. not screened) and, among those screened, the results (positive vs. negative), average time spent in the ED, and referral patterns for victim services.Principal FindingsDuring the study period, 65,563 unique patients with 95,555 encounters occurred. Seventy-one percent (n = 67,535) were screened for violence against persons and, of those, 2% screened positive (n = 1349). Of the patients who screened positive, 1178 (87%) were referred to and 806 (60%) received care at victim services. Implementing screening did not increase the length of stay at ED.ConclusionsSystematic implementation of comprehensive violence screening at a safety-net system can result in robust identification and timely referrals to victim services.